Carboxyl-Terminal Residues N478 and V479 Required for the Cytolytic Activity of Listeriolysin O Play a Critical Role in Listeria monocytogenes Pathogenicity

Listeria monocytogenes is a facultative intracellular pathogen that secretes the cytolysin listeriolysin O (LLO), which enables the bacteria to cross the phagosomal membrane. L. monocytogenes regulates LLO activity in the phagosome and minimizes its activity in the host cytosol. Mutants that fail to...

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Principais autores:	Changyong Cheng, Li Jiang, Tiantian Ma, Hang Wang, Xiao Han, Jing Sun, Yongchun Yang, Zhongwei Chen, Huifei Yu, Yi Hang, Fengdan Liu, Bosen Wang, Weihuan Fang, Huarong Huang, Chun Fang, Chang Cai, Nancy Freitag, Houhui Song
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2017-11-01
Serija:	Frontiers in Immunology
Teme:	Listeria monocytogenes listeriolysin O cytolytic activity virulence live vaccine
Online dostop:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01439/full
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