Carboxyl-Terminal Residues N478 and V479 Required for the Cytolytic Activity of Listeriolysin O Play a Critical Role in Listeria monocytogenes Pathogenicity

Listeria monocytogenes is a facultative intracellular pathogen that secretes the cytolysin listeriolysin O (LLO), which enables the bacteria to cross the phagosomal membrane. L. monocytogenes regulates LLO activity in the phagosome and minimizes its activity in the host cytosol. Mutants that fail to...

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Ngā kaituhi matua:	Changyong Cheng, Li Jiang, Tiantian Ma, Hang Wang, Xiao Han, Jing Sun, Yongchun Yang, Zhongwei Chen, Huifei Yu, Yi Hang, Fengdan Liu, Bosen Wang, Weihuan Fang, Huarong Huang, Chun Fang, Chang Cai, Nancy Freitag, Houhui Song
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2017-11-01
Rangatū:	Frontiers in Immunology
Ngā marau:	Listeria monocytogenes listeriolysin O cytolytic activity virulence live vaccine
Urunga tuihono:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01439/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!