USP13-Mediated selective autophagy of eIF5B promotes pathological cardiac hypertrophy

Abstract Pathological cardiac hypertrophy and heart failure pose significant global health challenges. Maintaining cardiomyocyte homeostasis is crucial for slowing disease progression. Our findings reveal that Ubiquitin-specific peptidase 13 (USP13), a key component of the Protein Quality Control (P...

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Detalhes bibliográficos

Principais autores:	Yutong Ye, Juan Xu, Chenyang Jin, XinTao Li, Xiaoyu Wu, Changzuan Zhou, Longzhe Gao, Zikan Zhong, Xudong Li, Songwen Chen, Yong Wei, Shi Peng, Shaowen Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-12-01
coleção:	Cellular and Molecular Life Sciences
Assuntos:	Deubiquitinating enzyme Proteostasis Transverse aortic constriction (TAC) Endoplasmic reticulum stress JNK signaling
Acesso em linha:	https://doi.org/10.1007/s00018-025-05980-7
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