DDX60 protects ischemic myocardial injury and heart dysfunction by improving mitochondrial function via promoting Arl2 mRNA translation

Abstract Mitochondrial dysfunction is increasingly recognized as a pivotal driver of cardiomyocyte apoptosis and cardiac deterioration following myocardial infarction (MI). This study identifies a significant upregulation of DDX60 in cardiomyocytes under hypoxic conditions. Elevated DDX60 levels enh...

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Detalhes bibliográficos

Principais autores:	Tianyou Yuan, Changzuan Zhou, Yifan Long, Xiaoqiang Chen, Longzhe Gao, Ya Li, Songwen Chen, Xiaofeng Lu, Juan Xu, Xiaoyu Wu, Genqing Zhou, Shaowen Liu, Wenyi Yang, Yong Wei, Lidong Cai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-09-01
coleção:	Cellular and Molecular Life Sciences
Assuntos:	Cardiomyocyte apoptosis Mitochondrial function Myocardial infarction DDX60 Arl2
Acesso em linha:	https://doi.org/10.1007/s00018-025-05839-x
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