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Z-DNA formation in promoters conserved between human and mouse are associated with increased transcription reinitiation rates

Abstract A long-standing question concerns the role of Z-DNA in transcription. Here we use a deep learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural properties of nucleotides and omics data. We examined Z-flipons that are conserved between human and mouse genomes after...

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Principais autores: Nazar Beknazarov, Dmitry Konovalov, Alan Herbert, Maria Poptsova
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2024-08-01
Serija:Scientific Reports
Online dostop:https://doi.org/10.1038/s41598-024-68439-y
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