TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway

IntroductionIntracerebral hemorrhage (ICH) often triggers oxidative stress through reactive oxygen species (ROS). Transforming growth factor-β-activated kinase 1 (TAK1) plays a pivotal role in regulating oxidative stress and inflammation across various diseases. 5Z-7-Oxozeaenol (OZ), a specific inhi...

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Auteurs principaux:	Jing Zhao, Chunli Chen, Lite Ge, Zheng Jiang, Zhiping Hu, Lihong Yin
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2024-05-01
Collection:	Frontiers in Immunology
Sujets:	intracerebral hemorrhage pyroptosis reactive oxygen species oxidative stress neuroinflammation NLRP3 inflammasome
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1386780/full
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