Ginsenoside Rg2 attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3-mediated pyroptosis

Abstract Background Intracerebral hemorrhage (ICH) is a devastating stroke subtype without effective therapy. Neuroinflammation, particularly driven by NLRP3 inflammasome–mediated pyroptosis, is a key contributor to secondary brain injury (SBI). Ginsenoside Rg2 (Rg2), a natural saponin with anti-inf...

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Autori principali:	Han Sun, Wenwen Fu, Zhiqiang Yao, Ying Sun, Huifeng Wang, Wenli Ma, Shunfang Zuo, Zihao Zhang, Shuting Feng, Jialin Chen, Yanbing Wu, Meng Cai, Huali Xu, Alexander Dityatev, Weilun Sun
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-03-01
Serie:	Journal of Neuroinflammation
Soggetti:	NLRP3 inflammasome Microglia Pyroptosis Neuroinflammation Intracerebral hemorrhage Ginsenoside Rg2
Accesso online:	https://doi.org/10.1186/s12974-026-03778-3
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