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Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma

Background: Multiple myeloma (MM) is an incurable plasma cell malignancy with high relapse rate. Recent studies have implicated dysregulated autophagy and ferroptosis in MM progression; however, the molecular links remain elusive. This study investigated the role of SDE2, a ubiquitin-like protein ov...

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Principais autores: Liang Xia, Jing Bao, Xiao-wen Chen, Yu-Chen Zhao, Xiang Wang, Yu Zheng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-04-01
Serier:Redox Biology
Fag:
Multiple myeloma
SDE2
ATG5
Autophagy
Ferroptosis
Ubiquitination
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231726000054
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