Neuron–Microglia Contacts Govern the PGE₂ Tolerance through TLR4-Mediated de Novo Protein Synthesis

Cellular and molecular mechanisms of the peripheral immune system (e.g., macrophage and monocyte) in programming endotoxin tolerance (ET) have been well studied. However, regulatory mechanism in development of brain immune tolerance remains unclear. The inducible COX-2/PGE₂ axis in microg...

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Hlavní autoři:	Hsing-Chun Kuo, Kam-Fai Lee, Shiou-Lan Chen, Shu-Chen Chiu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chun-Hsien Chu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-02-01
Edice:	Biomedicines
Témata:	PGE<sub>2</sub> COX-2 microglia endotoxin tolerance cell–cell contacts TLR4
On-line přístup:	https://www.mdpi.com/2227-9059/10/2/419
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