Neuron–Microglia Contacts Govern the PGE₂ Tolerance through TLR4-Mediated de Novo Protein Synthesis

Cellular and molecular mechanisms of the peripheral immune system (e.g., macrophage and monocyte) in programming endotoxin tolerance (ET) have been well studied. However, regulatory mechanism in development of brain immune tolerance remains unclear. The inducible COX-2/PGE₂ axis in microg...

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Autores principales:	Hsing-Chun Kuo, Kam-Fai Lee, Shiou-Lan Chen, Shu-Chen Chiu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chun-Hsien Chu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-02-01
Colección:	Biomedicines
Materias:	PGE<sub>2</sub> COX-2 microglia endotoxin tolerance cell–cell contacts TLR4
Acceso en línea:	https://www.mdpi.com/2227-9059/10/2/419
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