iRGD-functionalized PLGA nanocomplex co-loaded with paclitaxel and Trametes robiniophila Murr for targeted inhibition of chemoresistant and metastatic signaling gene PDCD4 in colon cancer

Abstract Background Metastasis and chemoresistance remain key challenges in colon tumor management. Integrating transcriptomic screening with molecular modeling may reveal actionable therapeutic targets for rational nanocomplex design. Methods Transcriptomic datasets GSE44076 (n = 98) and GSE253699...

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Bibliografski detalji

Glavni autori:	Li Li, Ying Liu, Xiao Wei, Rui Li, Wang Shuan, Mei Yan, Qun Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-04-01
Serija:	BMC Pharmacology and Toxicology
Teme:	PDCD4 CCND1 Colon tumor PTX–TP@PLGA–iRGD nanocomplex Molecular docking Transcriptomic integration
Online pristup:	https://doi.org/10.1186/s40360-026-01126-y
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