Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations

Abstract Cantú syndrome (CS), a multisystem disease with a complex cardiovascular phenotype, is caused by gain-of-function (GoF) variants in the Kir6.1/SUR2 subunits of ATP-sensitive potassium (KATP) channels and is characterized by low systemic vascular resistance, as well as tortuous, dilated, ves...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Alex Hanson, Conor McClenaghan, Kuo-Chan Weng, Sarah Colijn, Amber N Stratman, Carmen M Halabi, Dorothy K Grange, Jonathan R Silva, Colin G Nichols
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Physiological Society 2024-01-01
Sarja:	Function
Aiheet:	KATP KCNJ8 Kir6.1 ABCC9 SUR2 CRISPR
Linkit:	https://journals.physiology.org/doi/10.1093/function/zqae027
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