Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell KATP channels

ATP-sensitive potassium (KATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion. KATP channels are hetero-octameric complexes composed of four pore-forming subunits (Kir6.2, encoded by...

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Principais autores:	Natascia Vedovato, Frances M. Ashcroft, Brian Catchpole, Lucy J. Davison
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2025-10-01
סדרה:	Frontiers in Physiology
נושאים:	KATP channels ABCC8 and KCNJ11 genes multi-species studies pancreatic beta-cells Kir6.2
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1693112/full
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