Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification

Introduction: Endplate cartilage is crucial for nutrient transport to intervertebral disc (IVD), and its calcification due to abnormal mechanical stress significantly contributes to intervertebral disc degeneration (IDD). Primary cilia, which sense mechanical stimuli, are key to this process. Intraf...

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Autori principali:	Zhi-Rui Dong, Jing Wang, Yu-Kai Huang, Wang Ding, Huan-Xin He, Guang-Cheng Yuan, Zhi-Yang Gao, Yu-Xiang Ge, Wen-Xian Wang, Li-Bo Jiang, Ming-Dong Zhao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Journal of Advanced Research
Soggetti:	Endplate cartilage IFT88 Calcification TRPV4 Mechanical stress
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2090123225003601
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