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Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens

Abstract: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant. Identifying mHAs with high allele frequency, tight binding affinity to common HLA molecules, a...

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Autori principali: Jefferson L. Lansford, Udara Dharmasiri, Shengjie Chai, Sally A. Hunsucker, Dante S. Bortone, James E. Keating, Ian M. Schlup, Gary L. Glish, Edward J. Collins, Gheath Alatrash, Jeffrey J. Molldrem, Paul M. Armistead, Benjamin G. Vincent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018-08-01
Serie:Blood Advances
Accesso online:http://www.sciencedirect.com/science/article/pii/S247395292030882X
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