Effective serum concentration of high-dose methotrexate therapy for osteosarcoma with dose adjustment for pharmacokinetic parameters: a retrospective study

Abstract Background In high-dose methotrexate (MTX) (HD-MTX) therapy, a dosage regimen utilizing the pharmacokinetic (PK) parameters of individual patients (PK method) has been developed to successfully reduce the intra- and inter-individual variability of serum MTX concentration. In this study, we...

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Principais autores:	Ayumu Nagamine, Takuya Araki, Hideaki Yashima, Akane Kamimura, Takumi Shiraishi, Takashi Yanagawa, Kyoko Obayashi, Koujirou Yamamoto
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-12-01
叢編:	BMC Cancer
主題:	Event-free survival High-dose methotrexate Osteosarcoma Overall survival Pharmacokinetic Target concentration
在線閱讀:	https://doi.org/10.1186/s12885-025-15437-6
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