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Effective serum concentration of high-dose methotrexate therapy for osteosarcoma with dose adjustment for pharmacokinetic parameters: a retrospective study

Abstract Background In high-dose methotrexate (MTX) (HD-MTX) therapy, a dosage regimen utilizing the pharmacokinetic (PK) parameters of individual patients (PK method) has been developed to successfully reduce the intra- and inter-individual variability of serum MTX concentration. In this study, we...

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Principais autores: Ayumu Nagamine, Takuya Araki, Hideaki Yashima, Akane Kamimura, Takumi Shiraishi, Takashi Yanagawa, Kyoko Obayashi, Koujirou Yamamoto
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:BMC Cancer
Fag:
Event-free survival
High-dose methotrexate
Osteosarcoma
Overall survival
Pharmacokinetic
Target concentration
Online adgang:https://doi.org/10.1186/s12885-025-15437-6
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