Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland

Background:Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with Neurofibromatosis Type I (NF1)–a tumor predisposition syndrome caused by a germline NF1 mutation–have an increased risk of deve...

Descrición completa

Detalles Bibliográficos

Principais autores:	Menusha Arumugam, Elizabeth A. Tovar, Curt J. Essenburg, Patrick S. Dischinger, Ian Beddows, Emily Wolfrum, Zach B. Madaj, Lisa Turner, Kristin Feenstra, Kristin L. Gallik, Lorna Cohen, Madison Nichols, Rachel T. C. Sheridan, Corinne R. Esquibel, Ghassan Mouneimne, Carrie R. Graveel, Matthew R. Steensma
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-05-01
Series:	Frontiers in Cell and Developmental Biology
Assuntos:	NF1 mammary stroma adipocyte differentiation collagen
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1375441/full
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!