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Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland

Background:Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with Neurofibromatosis Type I (NF1)–a tumor predisposition syndrome caused by a germline NF1 mutation–have an increased risk of deve...

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Asıl Yazarlar: Menusha Arumugam, Elizabeth A. Tovar, Curt J. Essenburg, Patrick S. Dischinger, Ian Beddows, Emily Wolfrum, Zach B. Madaj, Lisa Turner, Kristin Feenstra, Kristin L. Gallik, Lorna Cohen, Madison Nichols, Rachel T. C. Sheridan, Corinne R. Esquibel, Ghassan Mouneimne, Carrie R. Graveel, Matthew R. Steensma
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2024-05-01
Seri Bilgileri:Frontiers in Cell and Developmental Biology
Konular:
NF1
mammary
stroma
adipocyte differentiation
collagen
Online Erişim:https://www.frontiersin.org/articles/10.3389/fcell.2024.1375441/full
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