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Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis.

Break-induced replication (BIR) has been implicated in restoring eroded telomeres and collapsed replication forks via single-ended invasion and extensive DNA synthesis on the recipient chromosome. Unlike other recombination subtypes, DNA synthesis in BIR likely relies heavily on mechanisms enabling...

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Principais autores: Jun Che, Stephanie Smith, Yoo Jung Kim, Eun Yong Shim, Kyungjae Myung, Sang Eun Lee
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Genetics
Acceso en liña:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004990&type=printable
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