Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that progerin‐driven vascular smooth musc...

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Autors principals:	Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2019-03-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	aging endoplasmic reticulum stress progeria unfolded protein response vascular smooth muscle cell
Accés en línia:	https://doi.org/10.15252/emmm.201809736
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