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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Summary: Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden vulnerabilities within therapy-induced phenotypes. Using a microscopy-...

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Principais autores: Sander Mertens, Maarten A. Huismans, Carla S. Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F. Boj, Hans Clevers, Jeanine M.L. Roodhart, Johannes L. Bos, Hugo J.G. Snippert
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-04-01
coleção:Cell Reports
Assuntos:
CP: Stem cell research
CP: Cancer
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124723003352
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