Activating KRAS mutations mark premalignant cystic structures in congenital pulmonary airway malformations

Abstract Background Congenital Pulmonary Airway malformations (CPAM) may lead to malignant degeneration, and therefore many surgeons opt to resect CPAM even in asymptomatic patients. Previously, we identified Kirsten rat sarcoma virus (KRAS) mutations in a subset of CPAM patients, possibly indicatin...

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Hauptverfasser:	Cathy van Horik, Floor Benthem, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Wilfred .F.J. van IJcken, Rene .M.H. Wijnen, Marco. Schnater, Robbert .J. Rottier
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-01-01
Schriftenreihe:	Respiratory Research
Schlagworte:	Congenital pulmonary airway malformations Organoids KRAS Mutations
Online-Zugang:	https://doi.org/10.1186/s12931-025-03491-4
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