Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

<p>Abstract</p> <p>Background</p> <p>BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In this work, the molecular mechanisms affected in human ce...

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Principais autores:	Iofrida Caterina, Melissari Erika, Mariotti Veronica, Guglielmi Chiara, Guidugli Lucia, Caligo Maria, Pellegrini Silvia
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2012-05-01
סדרה:	BMC Cancer
נושאים:	Gene expression Microarray analysis Missense mutations BRCA1 gene DNA damage DNA repair Genomic instability Cell proliferation Breast neoplasms Apoptosis
גישה מקוונת:	http://www.biomedcentral.com/1471-2407/12/207
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