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BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer

The <i>BRCA1</i> is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety of other proteins that play essential roles in gene regulation and embry...

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Principais autores: Tala Ismail, Safa Alzneika, Emna Riguene, Salwa Al-maraghi, Aya Alabdulrazzak, Noof Al-Khal, Sara Fetais, Angelos Thanassoulas, Halema AlFarsi, Michail Nomikos
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-03-01
coleção:Pharmaceuticals
Assuntos:
BRCA1 gene
breast cancer
ovarian cancer
BRCT domain
Acesso em linha:https://www.mdpi.com/1424-8247/17/3/333
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