Sipa1 deficiency–induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm

Abstract: Mutations of signal-induced proliferation-associated gene 1 (SIPA1), a RAP1 GTPase-activating protein, were reported in patients with juvenile myelomonocytic leukemia, a childhood myelodysplastic/myeloproliferative neoplasm (MDS/MPN). Sipa1 deficiency in mice leads to the development of ag...

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Autori principali:	Pingnan Xiao, Monika Dolinska, Lakshmi Sandhow, Makoto Kondo, Anne-Sofie Johansson, Thibault Bouderlique, Ying Zhao, Xidan Li, Marios Dimitriou, George Z. Rassidakis, Eva Hellström-Lindberg, Nagahiro Minato, Julian Walfridsson, David T. Scadden, Mikael Sigvardsson, Hong Qian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2018-03-01
Serie:	Blood Advances
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2473952920310776
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