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IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

Summary: The mammalian endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is essential for cellular homeostasis and plays key roles in infection responses, including innate immunity and microbicidal activity. While IRE1α functions through the IRE1α-XBP1S axis are known, it...

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Principais autores: Michael J. McFadden, Mack B. Reynolds, Britton C. Michmerhuizen, Einar B. Ólafsson, Sofia M. Marshall, Faith Anderson Davis, Tracey L. Schultz, Takao Iwawaki, Jonathan Z. Sexton, Mary X.D. O’Riordan, Teresa R. O’Meara
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:Cell Reports
Fag:
CP: Immunology
CP: Microbiology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124725004656
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