SIRT6-mediated immunometabolic reprogramming of macrophages drives neutrophilic asthma via LDHA-dependent glycolysis

Summary: Neutrophilic asthma is a steroid-resistant condition linked to immunometabolic dysregulation. While the NAD+-dependent deacetylase Sirtuin 6 (SIRT6) regulates immune responses, its role in neutrophilic asthma remains unknown. Utilizing multiple human samples and neutrophilic asthma murine m...

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Detalles Bibliográficos

Principais autores:	Guomei Su, Jiangyun Peng, Jingyun Quan, Zhihang Feng, Yu Zhong, Zhilin Xiong, Jiewen Huang, Zhao Zhao, Yingying Lv, Wenhong Hou, Lianxiang Luo, Xiao Li, Yiming Shao, Jielin Duan, Xiao Gao, Tianwen Lai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-05-01
Series:	Cell Reports
Assuntos:	CP: immunology CP: metabolism
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124726003724
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