Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice.

A knockin (KI) mouse expressing mutated prestinV499G/Y501H (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs wer...

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Hlavní autoři:	Mary Ann Cheatham, Roxanne M Edge, Kazuaki Homma, Emily L Leserman, Peter Dallos, Jing Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2015-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC4684303?pdf=render
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