Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss

2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss by destroying the outer hair cells (OHC). HPβCD-ind...

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Hlavní autoři:	Dalian Ding, Haiyan Jiang, Senthilvelan Manohar, Xiaopeng Liu, Li Li, Guang-Di Chen, Richard Salvi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-05-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	cyclodextrin prestin Niemann-Pick C1 spiral ganglion neurons outer hair cells inner hair cells
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2021.643709/full
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