Learning epistatic gene interactions from perturbation screens.

The treatment of complex diseases often relies on combinatorial therapy, a strategy where drugs are used to target multiple genes simultaneously. Promising candidate genes for combinatorial perturbation often constitute epistatic genes, i.e., genes which contribute to a phenotype in a non-linear fas...

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書誌詳細

主要な著者:	Kieran Elmes, Fabian Schmich, Ewa Szczurek, Jeremy Jenkins, Niko Beerenwinkel, Alex Gavryushkin
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2021-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	https://doi.org/10.1371/journal.pone.0254491
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