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Adaptation in protein fitness landscapes is facilitated by indirect paths

The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nicholas C Wu, Lei Dai, C Anders Olson, James O Lloyd-Smith, Ren Sun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications Ltd 2016-07-01
Cyfres:eLife
Pynciau:
Mynediad Ar-lein:https://elifesciences.org/articles/16965
Tagiau: Ychwanegu Tag
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