Clinical candidate and genistein analogue AXP107‐11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein‐coupled estrogen receptor signaling

Abstract Despite advances in cancer therapeutics, pancreatic cancer remains difficult to treat and often develops resistance to chemotherapies. We have evaluated a bioavailable genistein analogue, AXP107‐11 which has completed phase Ib clinical trial, as an approach to sensitize tumor cells to chemo...

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Bibliografiske detaljer

Principais autores:	Fahmi Mesmar, Bingbing Dai, Ahmed Ibrahim, Linnea Hases, Mohammed Hakim Jafferali, Jithesh Jose Augustine, Sebastian DiLorenzo, Ya'an Kang, Yang Zhao, Jing Wang, Michael Kim, Chin‐Yo Lin, Anders Berkenstam, Jason Fleming, Cecilia Williams
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2019-12-01
Serier:	Cancer Medicine
Fag:	AXP107‐11 chemoresistance genistein GPER1 pancreatic ductal adenocarcinoma
Online adgang:	https://doi.org/10.1002/cam4.2581
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