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Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Abstract Background Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive predictive marker of immunot...

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Principais autores: Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, Michael Knudsen, Maria Bach Laursen, Anders Husted Madsen, Lene Hjerrild Iversen, Kåre Gotschalck Sunesen, Mads Heilskov Rasmussen, Claus Lindbjerg Andersen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-10-01
coleção:BMC Cancer
Assuntos:
MSIsensor
Colorectal cancer
DNA mismatch repair deficiency
Microsatellite instability
MSI
MSS
Acesso em linha:http://link.springer.com/article/10.1186/s12885-019-6227-7
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