Molecular residual disease assessment in colorectal and bladder cancer by somatic structural variant analysis of cell-free DNA whole-genome sequencing data

Abstract Background Whole-genome sequencing (WGS)-based methods for circulating tumor DNA (ctDNA) detection typically rely on tumor-informed identification of somatic single nucleotide variants (SNVs). Somatic structural variants (SVs) are another type of cancer-specific genomic alteration, which ow...

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Bibliografiska uppgifter

Huvudupphov:	Ester Ellegaard Sørensen, Amanda Frydendahl, Mads Heilskov Rasmussen, Iver Nordentoft, Michael Knudsen, Tenna Vesterman Henriksen, Sia Viborg Lindskrog, Lars Dyrskjøt, Claus Lindbjerg Andersen, Jesper Bertram Bramsen
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2026-02-01
Serie:	Journal of Translational Medicine
Ämnen:	Structural variants Circulating tumor DNA Cell-free DNA Colorectal cancer Whole-genome sequencing ctDNA
Länkar:	https://doi.org/10.1186/s12967-026-07762-6
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