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Enhanced immunogenicity of a functional enzyme by T cell epitope modification

<p>Abstract</p> <p>Background</p> <p>T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation of recombinant protein-based vacci...

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Autors principals: Collier Kathy, Saldajeno Mae, Ganshaw Grant, Poulose AJ, Stickler Marcia M, Mucha Jeanette M, Huang Manley T, Harding Fiona A
Format: Artigo
Idioma:Inglês
Publicat: BMC 2002-01-01
Col·lecció:BMC Immunology
Accés en línia:http://www.biomedcentral.com/1471-2172/3/2
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