Unraveling the Structure of Meclizine Dihydrochloride with MicroED

Abstract Meclizine (Antivert, Bonine) is a first‐generation H1 antihistamine used in the treatment of motion sickness and vertigo. Despite its wide medical use for over 70 years, its crystal structure and the details of protein‐drug interactions remained unknown. Single‐crystal X‐ray diffraction (SC...

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Principais autores:	Jieye Lin, Johan Unge, Tamir Gonen
格式:	Artigo
語言:	Inglês
出版:	Wiley 2024-02-01
叢編:	Advanced Science
主題:	Meclizine (Antivert, Bonine) Microcrystal electron diffraction (MicroED) Molecular docking Protein‐drug interactions Racemic crystal
在線閱讀:	https://doi.org/10.1002/advs.202306435
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