Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Abstract Background The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases. Previously, we reported that lysine acet...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	BMC 2020-01-01
श्रृंखला:	Molecular Neurodegeneration
विषय:	Tauopathy Tau secretion Tau spreading Autophagy-lysosomal pathway p300/CBP
ऑनलाइन पहुंच:	https://doi.org/10.1186/s13024-019-0354-0
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