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Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Abstract Background The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases. Previously, we reported that lysine acet...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2020-01-01
Schriftenreihe:Molecular Neurodegeneration
Schlagworte:
Tauopathy
Tau secretion
Tau spreading
Autophagy-lysosomal pathway
p300/CBP
Online-Zugang:https://doi.org/10.1186/s13024-019-0354-0
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