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Predicting isoniazid resistance in Mycobacterium tuberculosis complex in New York State using whole-genome sequencing

ABSTRACT Isoniazid (INH) is a critical antibiotic used worldwide for the treatment and prophylaxis of tuberculosis. Drug resistance (DR) to INH is the single most common type of DR, mediated by multiple genes/loci, including katG, inhA, mabA, mabA-inhA, and the oxyR-ahpC intergenic region. Over the...

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Principais autores: Kruthikaben Patel, Joseph Shea, Pascal Lapierre, Tanya A. Halse, Donna Kohlerschmidt, Michelle Dickinson, Vincent Escuyer, Kimberlee A. Musser
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-04-01
Serier:Journal of Clinical Microbiology
Fag:
tuberculosis
isoniazid
drug resistance
whole-genome sequencing
katG
inhA
Online adgang:https://journals.asm.org/doi/10.1128/jcm.01609-25
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