Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific to tumor cells have...

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主要な著者:	Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2024-10-01
シリーズ:	Frontiers in Oncology
主題:	MR1 alloreactive T-cell (TCR) T-cell receptor cancer
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1419528/full
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