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Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific to tumor cells have...

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Furkejuvvon:
Váldodahkkit: Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2024-10-01
Ráidu:Frontiers in Oncology
Fáttát:
MR1
alloreactive
T-cell
(TCR) T-cell receptor
cancer
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fonc.2024.1419528/full
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