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FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Abstract Background Sjögren’s syndrome (SS) is a chronic systemic autoimmune disease in which CD4+ T cells play a critical role. Recent advances in immunometabolism suggest that metabolic reprogramming contributes to autoimmune pathogenesis. This study investigates the role of fatty acid synthase (F...

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Wedi'i Gadw mewn:
Prif Awduron: Lei Ye, Xijun Wang, Junhao Yin, Huan Shi, Jiayao Fu, Baoli Wang, Lingyan Zheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2026-02-01
Cyfres:Arthritis Research & Therapy
Pynciau:
Fatty acid synthase (FASN)
T cells
Metabolic reprogramming
Sjögren’s syndrome (SS)
Oxidative phosphorylation (OXPHOS)
Mynediad Ar-lein:https://doi.org/10.1186/s13075-026-03765-2
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