FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Abstract Background Sjögren’s syndrome (SS) is a chronic systemic autoimmune disease in which CD4+ T cells play a critical role. Recent advances in immunometabolism suggest that metabolic reprogramming contributes to autoimmune pathogenesis. This study investigates the role of fatty acid synthase (F...

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Hlavní autoři:	Lei Ye, Xijun Wang, Junhao Yin, Huan Shi, Jiayao Fu, Baoli Wang, Lingyan Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Arthritis Research & Therapy
Témata:	Fatty acid synthase (FASN) T cells Metabolic reprogramming Sjögren’s syndrome (SS) Oxidative phosphorylation (OXPHOS)
On-line přístup:	https://doi.org/10.1186/s13075-026-03765-2
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