Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

PLP overexpressing mice display demyelination and axonopathic changes, accompanied by an elevation of CD8+ T-lymphocytes and CD11b+ macrophages in the CNS. By crossbreeding these mutants with RAG-1-deficient mice lacking mature lymphocytes, we could recently demonstrate a pathogenetic impact of the...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Chi Wang Ip, Antje Kroner, Paul R. Crocker, Klaus-Armin Nave, Rudolf Martini
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2007-01-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	Microglia Macrophages T-lymphocytes Leukodystrophy Multiple sclerosis Animal model
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0969996106002166
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