Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

Abstract Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distin...

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Detalhes bibliográficos

Principais autores:	Janos Groh, Tassnim Abdelwahab, Yogita Kattimani, Michaela Hörner, Silke Loserth, Viktoria Gudi, Robert Adalbert, Fabian Imdahl, Antoine-Emmanuel Saliba, Michael Coleman, Martin Stangel, Mikael Simons, Rudolf Martini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-10-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-42570-2
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