Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage. Thus, treatment with galunisertib, a small molecule inhibitor of TGFβ recept...

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Auteurs principaux:	Matthis Desoteux, Betty Maillot, Kevin Bévant, Tanguy Ferlier, Raffaële Leroux, Gaëlle Angenard, Corentin Louis, Laurent Sulpice, Karim Boudjema, Cédric Coulouarn
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2023-07-01
Collection:	FEBS Open Bio
Sujets:	galunisertib gene signature hepatocellular carcinoma survival TGFβ
Accès en ligne:	https://doi.org/10.1002/2211-5463.13647
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