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Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines

Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly malignant liver tumor associated with a dismal prognosis, largely due to chemotherapy resistance. However, the mechanisms underlying gemcitabine (GEM) resistance in ICC remain poorly understood. In this study, we established three GEM-resist...

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Principais autores: Jiandong Li, Yanxin Hu, Jiayao Zhang, Weiguang Zhang, Jianhua Yu, Baochun Lu
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2025-02-01
叢編:Scientific Reports
在線閱讀:https://doi.org/10.1038/s41598-025-89423-0
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