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Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Abstract Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased lipid content in the pathogenesis of IPF remains undetermined. Methods...

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Principais autores: Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-04-01
coleção:Respiratory Research
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Acesso em linha:https://doi.org/10.1186/s12931-024-02816-z
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