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Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation

CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers on striatonigral neurons and their axon termi...

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Principais autores: José Arturo Avalos-Fuentes, Rodolfo Sánchez-Zavaleta, Ihosvany Rodríguez Pérez, Rafael Jijón-Lorenzo, Refugio Cruz-Trujillo, María Fernanda González de la Torre, Martha Abigail Villareal Zuñiga, Benjamín Florán
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
CB1 receptor
GPR55
heteromers
motor behavior
substantia nigra
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2026.1717829/full
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